Hi Tom,
I use Mailwasher. Like the one Rick mentioned, Mailwasher lets you view E-Mail at the server level and eliminate it there. It allows you to sign up with spam reporting agencies and will pre-mark everything that appears to be spam, and all you have to do to clear them all is "Process Mail". My one E-Mail address can get 200 to 300 spams a day, and this makes short work of them. Good Luck!
Scott.